Beneath the surface of the world, are the rules of science. But beneath them, there is a far deeper set of rules – a matrix of pure mathematics which explains the nature of the rules of science and how it is way we can understand them in the first place. In this one-off documentary, David Malone looks at four brilliant mathematicians – Georg Cantor, Ludwig Boltzmann, Kurt Gödel and Alan Turing – whose genius has profoundly affected us, but which tragically drove them insane and eventually led to them all committing suicide.