Amanda Knox is an American woman who after being convicted twice for murdering her fellow exchange student and roommate Meredith Kercher back in 2007. After spending nearly four years in an Italian prison Knox was definitively acquitted of the crime by the Supreme Court of Cassation in 2015.

Featuring interviews with Amanda Knox herself, her ex-boyfriend Raffaele Sollecito, Italian prosecutor Giuliano Mignini, and others involved in the case, this film chronicles the murder of Meredith Kercher and details the investigation and trials which followed.