Plan of Action: How the Spinal Cord Controls Movement

Thomas M. Jessell, Howard Hughes Medical Institute Investigator, examines the neural circuits that control our movements. Neural circuits give us a glimpse of how brain wiring and circuit activity control specific behaviors, including the movement of our limbs. Consider baseball player Lou Gehrig’s remarkable hand-eye coordination, or the purity of cellist Jacqueline du Pré’s tone. Yet, both examples also remind us of the fragility of the motor system: Gehrig succumbed to amyotrophic lateral sclerosis and du Pré to multiple sclerosis. Neural circuits, sensory feedback systems and signals from the brain permit us to change motor strategies to accommodate to an ever-changing world.

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  1. this was great. At the end a student asks if there is any research NOT based on disease. The speaker went into a applied vs.pure research answer which I believe missed the point. What about developmental disabilities? Not an outside pathogen like virus but an anomalous brain structure that causes the motor skills to be impaired?

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