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In one case of death buy provera 5mg cheap menstrual period calendar, the amount of acutely ingested olanzapine was reported to be possibly as low as 450 mg order provera 2.5 mg fast delivery womens health 7 day detox; however 10 mg provera mastercard pregnancy in dogs, in another case purchase cialis 5 mg free shipping, a patient was reported to survive an acute olanzapine ingestion of 1500 mg purchase generic kamagra super pills. The possibility of multiple drug involvement should be considered order zenegra with mastercard. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. Gastric lavage (after intubation, if patient is unconscious) and administration of activated charcoal together with a laxative should be considered. The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. Therefore, appropriate supportive measures should be initiated. Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids and/or sympathomimetic agents. Symptoms of overdose may include drowsiness and slurred speech. Other symptoms may include may include somnolence, mydriasis, blurred vision, respiratory depression, hypotension, and possible extrapyramidal disturbances. Usual Dose -- Oral olanzapine should be administered on a once-a-day schedule without regard to meals, generally beginning with 5 to 10 mg initially, with a target dose of 10 mg/day within several days. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, since steady state for olanzapine would not be achieved for approximately 1 week in the typical patient. When dosage adjustments are necessary, dose increments/decrements of 5 mg QD are recommended. Efficacy in schizophrenia was demonstrated in a dose range of 10 to 15 mg/day in clinical trials. However, doses above 10 mg/day were not demonstrated to be more efficacious than the 10 mg/day dose. An increase to a dose greater than the target dose of 10 mg/day (i. The safety of doses above 20 mg/day has not been evaluated in clinical trials. Dosing in Special Populations -- The recommended starting dose is 5 mg in patients who are debilitated, who have a predisposition to hypotensive reactions, who otherwise exhibit a combination of factors that may result in slower metabolism of olanzapine (e. When indicated, dose escalation should be performed with caution in these patients. Maintenance Treatment -- While there is no body of evidence available to answer the question of how long the patient treated with olanzapine should remain on it, the effectiveness of oral olanzapine, 10 mg/day to 20 mg/day, in maintaining treatment response in schizophrenic patients who had been stable on ZYPREXA for approximately 8 weeks and were then followed for a period of up to 8 months has been demonstrated in a placebo-controlled trial ( see CLINICAL PHARMACOLOGY ). Patients should be periodically reassessed to determine the need for maintenance treatment with appropriate dose.

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