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When two bulky groups are staggered we get the anti conformation discount 10mg reglan gastritis diet , and when they are at 60 to each other generic 10mg reglan otc gastritis diet patient education, we have the gauche conformer discount 10 mg reglan mastercard. The order of stability (from the highest to the lowest) among the following conformers is anti! The rotation about C–C bonds is quite restricted in cycloalkanes, especially in smaller rings, e. H H H H H H Cyclopropane 3 In cyclopropane, each C atom is still sp -hybridized, so we should have a bond angle of 109. The angle strain can be defined as the strain induced in a molecule when bond angle deviates from the ideal tetrahedral value. Conformational isomerism in cyclobutane Cyclobutane comprises four carbons and eight hydrogen atoms (C4H8). However, cyclobutane in its planar form will give rise to torsional strain, since all H atoms are eclipsed. H H H H H H H H H H H H H H H Cyclobutane as a planar molecule H All H atoms are eclipsed Most stable folded conformation of cyclobutane Bond angle = 90o H atoms are not eclipsed Cyclobutane, in fact, is not a planar molecule. To reduce torsional strain, this compound attains the above nonplanar folded conformation. Hydrogen atoms are not eclipsed in this conformation and torsional strain is much less than in the planar structure. However, in this form angles are less than 90 , which means a slight increase in angle strain. Conformational isomerism in cyclopentane Cyclopentane is a five- carbon cyclic alkane. However, in this form the torsional strain is very large, because most of its hydrogen atoms are eclipsed. Thus, to reduce torsional strain, cyclopentane twists to adopt a puckered or envelope shaped, nonplanar conformation that strikes a balance between increased angle strain and decreased torsional strain. H H H H H H H H H H H H H H H H H H H H Cyclopentane as a planar molecule Most stable puckered conformation of cyclopentane Bond angle = 108o Most H atoms are nearly staggered Conformational isomerism in cyclohexane Cyclohexane (C6H12)isa six-carbon cyclic alkane that occurs extensively in nature. If we consider cyclohexane as a planar and regular hexagon, the 3 angles are 120 (cf. H H H H H H H H H H H H 4 H H 1 H H H 5 6 H H H H H H H H H H H 3 H H H H 2 H H H H Cyclohexane as a planar molecule Most stable chair conformation Boat conformation of cyclohexane Bond angle 120o of cyclohexane All neighbouring C-H bonds are staggered 3. To strike a balance between torsional strain and angle strain, and to achieve more stability, cyclohexane attains various conformations, among which the chair and boat conformations are most significant. In the chair conformation, the C–C–C angles can reach the strain free tetrahedral value (109. Here the H atoms on C2–C3 and C5–C6 are eclipsed, which results in an increased torsional strain. In the chair conformation of cyclohexane, there are two types of position for the substituents on the ring, axial (perpendicular to the ring, i. Six hydrogen atoms are in the axial positions and six others in the equatorial positions.

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